BAY 1238097 ( BAY1238097 )

产品货号. M12230 CAS No. 1564268-08-1

COA

Datasheet

HNMR

HPLC

MSDS

Handing Instructions

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产品名称

BAY 1238097
注意事项

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断
产品简述

BAY 1238097 is a novel BET bromodomain inhibitor with IC50 of 50 nM.
产品描述

BAY 1238097 is a novel BET bromodomain inhibitor with IC50 of 50 nM, inhibits the interaction between BRD4, BRD3 or BRD2 and H4 with IC50 values of 63 nM, 609 nM and 2430 nM in the NanoBRET assay; shows selectivity of the compound for BRD4; strongly reduces c-Myc transcript and protein levels in MOLM-13 (AML) and MOLP-8 (MM) cell lines; exhibits strong efficacy in the AML models THP-1, MOLM-13 and KG-1.
同义词

BAY1238097
通路

Chromatin/Epigenetic
靶点

Bromodomain
受体

Bromodomain
研究领域

——
适应症

——

CAS Number

1564268-08-1
分子量

451.57
分子式

C25H33N5O3
纯度

>98% (HPLC)
溶解度

DMSO : 150 mg/mL 332.18 mM
SMILES

O=C(N1N=C(C2=CC=C(N3CCN(C)CC3)C=C2)C4=CC(OC)=C(OC)C=C4C[C@@H]1C)NC
化学全称

(S)-7,8-dimethoxy-N,4-dimethyl-1-(4-(4-methylpiperazin-1-yl)phenyl)-4,5-dihydro-3H-benzo[d][1,2]diazepine-3-carboxamide

1. Bernasconi E, et al. Br J Haematol. 2017 Jun 27. doi: 10.1111/bjh.14803.
2. Patent WO2014026997A1.

计算器

产品手册

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